NAOC Open IR
Research on rat's pulmonary acute injury induced by lunar soil simulant
Sun, Yan1,2; Liu, Jin-Guo2; Zheng, Yong-Chun3; Xiao, Chun-Ling1; Wan, Bing4; Guo, Li1; Wang, Xu-Guang1; Bo, Wei1
2018-02-01
Source PublicationJOURNAL OF THE CHINESE MEDICAL ASSOCIATION
ISSN1726-4901
Volume81Issue:2Pages:133-140
AbstractBackground: The steps to the moon never stopped after the Apollo Project. Lessons from manned landings on the moon have shown that lunar dust has great influence on the health of astronauts. In this paper, comparative studies between the lunar soil simulant (LSS) and PM2.5 were performed to discover their harm to human biological systems and explore the methods of prevention and treatment of dust poisoning for future lunar manned landings. Methods: Rats were randomly divided into the control group, two CAS-1 lunar soil simulant groups (tracheal perfusion with 7 mg and 0.7 mg, respectively, in a 1-mL volume) and the PM2.5 group (tracheal perfusion with 0.7 mg in a 1-mL volume). The biochemical indicators in the bronchoalveolar lavage fluid (BALF), MPO activity in the lung tissue, pathologic changes, and inflammatory cells in the BALF were measured after 4 h and 24 h. Results: The LSS group showed cytotoxicity that was closely related to the concentration. The figures of the two LSS groups (4 and 24 h) show that the alveolar septa were thickened. Additionally, it was observed that neutrophils had infiltrated, and various levels of inflammation occurred around the vascular and bronchial structures. Conclusion: The overall results of the acute effects of the lungs caused by dust showed that the lung toxicity of LSS was greater than that of PM2.5. LSS could induce lung damage and inflammatory lesions. The biomarkers in BALF caused by acute injury were consistent with his-topathologi c observations. Copyright (C) 2017, the Chinese Medical Association. Published by Elsevier Taiwan LLC.
KeywordAcute injury Lunar soil simulant Lung Rat
Funding OrganizationScience and Technology Research Fund of Shenyang Medical College ; Science and Technology Research Fund of Shenyang Medical College ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; National Science Foundation of China ; National Science Foundation of China ; Research Fund of China Manned Space Engineering ; Research Fund of China Manned Space Engineering ; Science and Technology Development Fund of Macau ; Science and Technology Development Fund of Macau ; Science and Technology Research Fund of Shenyang Medical College ; Science and Technology Research Fund of Shenyang Medical College ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; National Science Foundation of China ; National Science Foundation of China ; Research Fund of China Manned Space Engineering ; Research Fund of China Manned Space Engineering ; Science and Technology Development Fund of Macau ; Science and Technology Development Fund of Macau ; Science and Technology Research Fund of Shenyang Medical College ; Science and Technology Research Fund of Shenyang Medical College ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; National Science Foundation of China ; National Science Foundation of China ; Research Fund of China Manned Space Engineering ; Research Fund of China Manned Space Engineering ; Science and Technology Development Fund of Macau ; Science and Technology Development Fund of Macau ; Science and Technology Research Fund of Shenyang Medical College ; Science and Technology Research Fund of Shenyang Medical College ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; National Science Foundation of China ; National Science Foundation of China ; Research Fund of China Manned Space Engineering ; Research Fund of China Manned Space Engineering ; Science and Technology Development Fund of Macau ; Science and Technology Development Fund of Macau
DOI10.1016/j.jcma.2016.10.016
WOS KeywordBRONCHOALVEOLAR LAVAGE ; OXIDATIVE STRESS ; IN-VITRO ; ACTIVATION ; SURFACE ; MICE ; INFLAMMATION ; PARTICLES ; TOXICITY ; FUTURE
Language英语
Funding ProjectScience and Technology Research Fund of Shenyang Medical College[20171020] ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department[20170520437] ; National Science Foundation of China[51775541] ; Research Fund of China Manned Space Engineering[030201] ; Science and Technology Development Fund of Macau[020/2014/A1]
Funding OrganizationScience and Technology Research Fund of Shenyang Medical College ; Science and Technology Research Fund of Shenyang Medical College ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; National Science Foundation of China ; National Science Foundation of China ; Research Fund of China Manned Space Engineering ; Research Fund of China Manned Space Engineering ; Science and Technology Development Fund of Macau ; Science and Technology Development Fund of Macau ; Science and Technology Research Fund of Shenyang Medical College ; Science and Technology Research Fund of Shenyang Medical College ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; National Science Foundation of China ; National Science Foundation of China ; Research Fund of China Manned Space Engineering ; Research Fund of China Manned Space Engineering ; Science and Technology Development Fund of Macau ; Science and Technology Development Fund of Macau ; Science and Technology Research Fund of Shenyang Medical College ; Science and Technology Research Fund of Shenyang Medical College ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; National Science Foundation of China ; National Science Foundation of China ; Research Fund of China Manned Space Engineering ; Research Fund of China Manned Space Engineering ; Science and Technology Development Fund of Macau ; Science and Technology Development Fund of Macau ; Science and Technology Research Fund of Shenyang Medical College ; Science and Technology Research Fund of Shenyang Medical College ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; National Science Foundation of China ; National Science Foundation of China ; Research Fund of China Manned Space Engineering ; Research Fund of China Manned Space Engineering ; Science and Technology Development Fund of Macau ; Science and Technology Development Fund of Macau
WOS Research AreaGeneral & Internal Medicine
WOS SubjectMedicine, General & Internal
WOS IDWOS:000425706600008
PublisherELSEVIER TAIWAN
Citation statistics
Document Type期刊论文
Identifierhttp://ir.bao.ac.cn/handle/114a11/37421
Collection中国科学院国家天文台
Corresponding AuthorSun, Yan
Affiliation1.Shenyang Med Coll, Huanghebei St 146, Shenyang, Liaoning, Peoples R China
2.Chinese Acad Sci, Shenyang Inst Automat, State Key Lab Robot, Shenyang, Liaoning, Peoples R China
3.Chinese Acad Sci, Natl Astron Observ, Beijing, Peoples R China
4.Shenyang Med Coll, Cent Hosp, Lab Med, Shenyang, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Sun, Yan,Liu, Jin-Guo,Zheng, Yong-Chun,et al. Research on rat's pulmonary acute injury induced by lunar soil simulant[J]. JOURNAL OF THE CHINESE MEDICAL ASSOCIATION,2018,81(2):133-140.
APA Sun, Yan.,Liu, Jin-Guo.,Zheng, Yong-Chun.,Xiao, Chun-Ling.,Wan, Bing.,...&Bo, Wei.(2018).Research on rat's pulmonary acute injury induced by lunar soil simulant.JOURNAL OF THE CHINESE MEDICAL ASSOCIATION,81(2),133-140.
MLA Sun, Yan,et al."Research on rat's pulmonary acute injury induced by lunar soil simulant".JOURNAL OF THE CHINESE MEDICAL ASSOCIATION 81.2(2018):133-140.
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